Study demonstrates effectiveness of skinbetter science Alto Defense Serum

A recent study published in the Journal of Aesthetic and Clinical Dermatology has shown the efficacy of skinbetter science’s Alto Defense Serum. 

Alto Defense Serum is an advanced antioxidant serum formulated with WEL, an exclusive technology that deploys a combination of 19 powerful antioxidant ingredients, designed to work together to provide a new level of comprehensive and dynamic defence against free radicals.

As part of the study, which was funded by skinbetter science, investigators sought to evaluate the antioxidant capacity of WEL-DS, its ability to protect skin against the oxidizing effects of UVA/UVB radiation, and to assess the effectiveness and tolerability of WEL-DS for visible improvements in facial photodamage.

In-vitro testing utilized a hydrogen peroxide assay to detect activity in human skin explants following application with WEL-DS, a leading antioxidant serum (L-AOX), and a saline control.  Clinical studies included a minimal erythema dose (MED) trial in female subjects, aged 35 to 60 years. Skin was initially irradiated to determine each subject’s MED. WEL-DS was applied for four days to one site on the lower back of subjects; the other site remained untreated.  Both sites were irradiated with 1X, 2X and 3X each subject’s MED, digital images were obtained, and punch biopsies were collected from the 3X MED irradiated areas for histological analysis. A second clinical study evaluated efficacy and tolerability of twice daily application of WEL-DS in female subjects, aged 25 to 65 years with mild-to-moderate photodamage. Changes in fine lines/wrinkles, dyschromia, erythema, skin tone, pores, and tolerability were assessed at baseline and Weeks 4, 8, and 12. A subset of subjects were evaluated through Week 16.

Alto Defense Serum was found to deliver a significant capacity to reduce oxidative stress over time, compared to a top-selling antioxidant competitor. Skin treated with Alto Defense Serum encountered 53% less oxidative stress versus a top -selling antioxidant in Test 1 and 41% in Test 2.

Treatment with Alto Defense Serum also showed statistically significant reductions in UV-induced redness as demonstrated via Minimal Erythema Dose (MED) assessment. It also demonstrated cellular protective effects versus untreated irradiated skin.

WEL-DS demonstrated average improvements from baseline of 37 percent, fine lines/wrinkles; 17 percent, skin tone; 13 percent, dyschromia; 18 percent, erythema; and four percent, pores (N=21; Week 12).

In a 12 week study, 100% of subjects agreed that Alto Defense Serum was cosmetically elegant with a light texture and feel, absorbed well and works well with make-up.

Continued improvements were demonstrated in all parameters in an extension study (n=14; week 16). WEL-DS was well-tolerated.

The study can be read by visiting jcadonline.com/antioxidants-april-2019/