Mesotherapy safety and complication management outlined in paper

Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardised therapy parameters, so as to minimise the risk of potential adverse reactions, according to a paper published in the latest issue of The Journal of Cosmetic Dermatology. 

Mesotherapy involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardisation processes.

The aim of the paper was to summarise all the mesotherapy‐related complications published so far, and to provide an insight into their management.

Articles were derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines.

“The literature contained a number of case series and isolated case reports describing various side effects of different severities”, the authors wrote. “The therapeutic management of these complications is—in most cases—individualised.”