How polynucleotides technology can be used in skin rejuvenation

Before and after third session with Juvenus

Have you heard about Juvenus? It is an injectable skin booster for the face and body that helps restructure and rejuvenate the skin based on PDRN technology.

Juvenus contains natural HMW polynucleodtides in a sterile and reabsorbable gel. The polynucleotides attract water molecules and serve as a free radical scavenger, creating an ideal environment for fibroblast growth. 

What are polynucleotides?

 “Polynucleotide gels are not ‘fillers’ and are completely absorbed, with a half-life of approximately three hours”, explains Dr Agnieszka Surowiecka MD, PhD“This means that polynucleotides present the broadest spectrum of action through hydration, antioxidation and stimulation of fibroblasts. They increase the ability of skin fibroblasts to synthesize collagen, elastin and endogenous hyaluronic acid by ensuring an optimal extracellular environment [1]. Furthermore, they stimulate the natural mechanisms of tissue reconstruction and repair [2,3] and have anti-inflammatory properties [10]. Polynucleotides have been used successfully in the treatment of chronic wounds, including those associated with vascular ulceration or diabetes [3]". 

Join Croma’s live webinar on Tuesday, March 1

If you would like to find out more about polynucleotides technology and how it can be used in skin rejuvenation for the face and body, please join Croma's live webinar with Dr Agnieszka Surowiecka MD, PhD on Tuesday, March 1 at 6pm. 

Introducing Juvenus - polynucleotides for face and body rejuvenation 

Tuesday, March 1, 6pm GMT

*This webinar is intended for HCP's only. To register, please contact your local Croma representative or register your interest by clicking HERE.

 Agnieszka Surowiecka Speaker: Agnieszka Surowiecka MD, PhD

A general surgeon with a doctorate in plastic surgery, Agnieszka Surowiecka works in the field of aesthetic and regenerative medicine. She is the author of several papers in the fields of transplantation, surgery and aesthetic medicine, and her main interests are stem cells and wound healing.


  1. Iorizzo M., De Padova M.P., Tosti A. Biorejuvenation: theory and practice. Clin Dermatol 2008, 26(2), 177-181.
  2. Kim, J.H., Kwon, T., Lee, S.E. et al. Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler. Sci Rep 2020, 10, 5127.
  1. Galeano M., Bitto A., Altavilla D., Minutoli L., Polito F. et al. Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse. Wound Repair Regen. 2008, 16, 208-217Iorizzo M., De Padova M.P., Tosti A. Biorejuvenation: theory and practice. Clin Dermatol 2008, 26(2), 177-181.