New mechanism underlying IL-31-induced atopic dermatitis
Published
12th Feb 2018
An article published in the Journal of Allergy and Clinical Immunology has showed a new mechanism underlying T helper type 2 cell-released interleukin 31 (IL-31)-induced atopic dermatitis (AD).
The objective of the study was to investigate the function of brain-derived natriuretic peptide (BNP) in the peripheral sensory system and skin in IL-31-induced itch and neuro-epidermal communication in AD.
The study showed that BNP is implicated in AD and that IL-31 regulates BNP in skin. IL-31 enhances BNP release and synthesis and orchestrates cytokine and chemokine release from skin cells, thereby coordinating the signalling pathways involved in itch. Inhibiting peripheral BNP function may be a novel therapeutic strategy for AD and pruritic conditions.
To read the abstract follow this link https://www.ncbi.nlm.nih.gov/pubmed/29427643
